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Consistent with our data highlighting the importance of full-length huntingtin, disrupted calcium signaling in an HD mouse model requires the polyglutamine expansion in the context of the full huntingtin protein (66).
Overall these results demonstrate that β-cell mass expansion in the context of obesity brings about a subtle, but coordinated increase in the basal level of a wide array of genes involved in the inflammatory and autoimmune response of ob/ob islets that does not occur in PPARγ2-ablated POKO islets.
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Overall, these results suggest that clonal expansions in the context of reduced repertoire may be a defining feature of SLE, however, increases in disease activity are not reflected with immunological changes at the total T cell repertoire level.
The effect of third order dispersion on continuum expansion is discussed in the context of an optimum degree of pump coherence.
4 5 This expansion has occurred in the context of rising rates of health insurance coverage and healthcare costs.
As a consequence, Kitchen et al.'s estimation of a period of ∼20 ky of population occupation in Beringia based on the time interval between the "two expansions" is meaningless in the context of the peopling of Beringia or the Americas.
This trans-disciplinary expansion is particularly needed in the context of China as environmental issues are mostly tackled among scholars of natural and social sciences with a clear applied orientation.
As such, the latest data need to be treated with a degree of caution.A good performance, under the circumstancesWith this caveat, the latest data paint a picture of a moderately robust economic expansion, rendered more encouraging in the context of a collapse in private housing investment that knocked 0.3 percentage points off growth in the quarter.
In this study, we analyzed the expansion of CD33rSIGLEC genes in the context of evolution of aging.
The goal of this study was, using the example of Poland, to assess public acceptance of the expansion of nature conservation in the context of sustainable development principles and to discover whether existing nature governance should be modified when establishing new protected areas.
However in these studies, a small number of TCR sequences was obtained from a potentially vast underlying diversity of TCR sequences (Robins et al., 2009) and clonal expansion was determined only in the context of particular Vβ-chain usages.
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