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Coinciding with the expansion in application of intravitreal injections, post-injection endophthalmitis (PIE) is a potentially devastating complication despite a low incidence rate (approximately 0.05% depending on meta-analysis) [2].
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Additional oncological applications of PET are rapidly being developed and there is likely to be further expansion in applications with the availability of new positron-emitting radiopharmaceuticals for clinical use [ 2– 4].
This expansion in the application of interlocks has benefited from the integration of other emerging technologies into interlock systems.
Immunocytochemical is still the standard method for tumour cell detection, but in the last years, there is a rapid expansion in the application of molecular PCR-based methods to detect isolated tumour cells in haematological fluids.
It will experience expansion in its applications to integral membrane protein targets and, in its role as a target structure determination method, will be complemented by cryo-electron microscopy.
While early studies in trigeminal autonomic headache were done exclusively with positron emission tomography (PET), the development of new imaging techniques as well as the increase in image resolution have led to an expansion in the applications of magnetic resonance (MR) based imaging methods in headache.
The procedure of extracting TILs, priming and expansion in vitro and application to the host over longer periods is technically demanding and laborious, thus expense will be a limiting factor for the design of larger clinical trials.
We examine the utility of a generalised, non-Gaussian Karhunen Loéve expansion in nuclear engineering applications.
In the future, it is likely that small molecule or peptide-coated QDs will have better opportunities for development and expansion in in vivo applications than protein or antibody-conjugated QDs. Figure 11 Schematic illustration of the formation of dendron-coated QDs.
One of the major challenges facing the expansion of using composite materials in application is the notch effect.
In any event, the relative paucity of stem/progenitor phenotypes highlights the need for early sorting of HFK cells according to marker molecules followed by their expansion in vitro rater than application of multipassage culture of unsorted heterogeneous HFK cells for cell selection (Loo et al. 2008).
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