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Porta, S., Kwong, L. K., Trojanowski, J. Q. & Lee, V. M. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases.
In the lineage expansion (cases 1 3) and constant fitness [15] models, there is a minimum value of α, which we term α50%, at which mutator pathways are expected to contribute to half of clinical cancers, and above which mutator pathways predominate.
There was no difference in the number of RBM45 inclusions within glia in C9ORF72 repeat expansion cases.
Clinically, C9ORF72 expansion cases with motor neuron dysfunction show features of classical ALS with a relatively rapidly progression.
In keeping with previous descriptions of C9orf72 expansion cases ubiquilin-2 inclusions were found in both cerebellum and hippocampus (Fig. 3c, g).
For expansion cases (Fig. 2), this test was always very significant provided the period of time used to calculate RN is long enough.
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In general, the number of the effective terms of the resultant theories is much lower than the full expansion case amount.
For the bandwidth expansion case, [5] obtains the result that the fastest decay speed of the mean square error (MSE) cannot be better than the square inverse of the SNR.
As in the constant fitness case [15], and the incremental lineage expansion case (case 1 above), we approximate mutator pathways by considering mutator mutations occurring as an initial step in tumorigenesis.
In the cooperative lineage expansion case with late mutator mutation, a greater fitness advantage increases the pool of cells which may acquire a late mutator mutation.
In case 2, the cooperative lineage expansion case with early mutator mutation, there is no increase in fitness until a subset of oncogenic mutations have been acquired, at which point the fitness increases rapidly and lineage expansion begins.
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