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Expansion microscopy (ExM), a method for improving the resolution of light microscopy by physically expanding the specimen, has not been applied to clinical tissue samples.
A new approach to image fixed biological samples by expanding the specimen under study reveals mouse brain substructures.
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An additional advantage of this approach is that probes may be generated using paraffin-embedded material, greatly expanding the available specimens for analysis.
We expanded the initial specimen set to the total of 33 RP specimens from patients with adenocarcinoma of prostate and 26 BPH control specimens for the interrogation with the six selected FISH probes.
The three-year GEIS Acinetobacter Surveillance Initiative demonstrated the value of standardized operating procedures and central specimen archives in expanding the knowledge base for these unique, but all too common, infections.
Thus, there are clear reasons for large collections of specimens, and for expanding the NINDS Repository ALS collection in the future should that be possible.
Expanding the Scope.
NIST is working with NOAA and its collaborating partners to expand the scope of the specimen bank and develop it as a resource of samples for animal health research.
By providing an alternative to DNA, osteocalcin could expand the range of specimens that can be used to test evolutionary hypotheses, he says.
To expand the number of specimens available for the present study, prostatectomy samples that had been formalin fixed and paraffin embedded (FFPE) were used, with modifications made to standard protocols to increase the yield of material used for sequencing.
These specimens expand the cranial growth series of this well known dinosaur, which will be described in an upcoming book by Mark and Jack.
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