Because preferential binding of Fbs1 to glycosylated isoforms of Skp1 occurred in binary isolation, it is likely that the sugars either influence the conformation of the F-box binding region of Skp1 or expand the interaction surface that is recognized by Fbs1.
To further support our conclusion that gene duplication can, indeed, lead to the evolution of novel function by expanding the epistatic interaction network, we first investigated how epistatic-interaction partners of duplicate gene pairs and singletons are distributed.
TAG-eCLIP enables eCLIP profiling of new native proteins where no suitable antibody exists, expanding the RBP-RNA interaction landscape.
Then, by expanding the potential of interaction of BP with the defect, U d (z0), in a series near this point and taking Equation 2 into account, we can write down U d z 0 = U 0 1 − z 0 2 / 2 Λ 2 (14).
(51) that relied on SILAC-based quantitative mass spectrometry (MS), 115 proteins were found to bind TERRA, vastly expanding the telomere DNA RNA protein interaction network and deepening our understanding of TERRA regulation.
Expanding the class of interactions from linear models to non-linear models is an important research topic.
Expanding the study of interactions to the whole genome, Kam-Thong et al. (2012) presented a whole genome analysis of epistasis (SNP-by-SNP) on several traits, including hippocampal volume.
It is conceivable that the inclusion of a coiled-coil domain with dimerization and target-binding capabilities may radically expand the overall interaction diversity of IDPs, allowing them to act as "hubs" in protein−protein interaction networks.
In order to expand the genetic interaction data set for Glc7, we examined a novel catalytic mutant, glc7-E101Q, for synthetic lethal interactions using SGA.
Given that users design feedback is gathered with the purpose of expanding on the interaction data from usability testing, or with the aim of benefitting from users knowledge and creativity, it is relevant to know whether users' design feedback actually generate findings that are different to what one could have reached through other data sources.
