Sentence examples for expanded variant from inspiring English sources

The results show that, compared to normal PABPN1, the interaction with Hsp70 is stronger for the expanded protein with 14 alanines and even stronger for the expanded variant with 17 alanines (Fig. 3).

At the start of aggregation the expanded variant AT3Q55 also showed a distribution of globular particles of variable size (Fig. 6A), with a mean height of 3.1±0.2 nm.

Thus, our results also demonstrate that the rearrangement of glutamine side chains and the resulting side-chain hydrogen bonding observed in the expanded variant is the key event resulting in the generation of irreversible aggregates.

The expanded variant of KCNN3 has been reported to reduce channel conductance and is associated with better cognitive performance of individuals with schizophrenia [ 57].

The presence of this helical-segment in expanded variants of PABPN1 could modulate their interactions properties by changing partner specificity and/or affinity.

Moreover, bacteria harbor a wide range of two-component systems (TCS) and their expanded variants known as phosphorelays to adapt to environmental conditions.

Thereafter, the applicability of the original model was improved in several studies that discussed the limitations and developed different expanded variants of the original work (Cowling & Pressey, 2003; Knight et al., 2006 a, b, 2011 a ; Conservation Measures Partnership, 2007; Margules & Sarkar, 2007; Pressey & Bottrill, 2009; Sarkar & Illoldi-Rangel, 2010).

Taking advantage of several analytical methods, especially FTIR spectroscopy, we provide here an in-depth analysis of such changes in a normal and an expanded AT3 variant, as well as in the JD in isolation.

Therefore, based on our results, these are the hallmarks of mature fibrils generated by expanded AT3 variants.

Tryptophan emission fluorescence spectra were recorded in response to the addition of increasing amounts of purified recombinant Hsp70 to purified recombinant normal and expanded PABPN1 variants.

On the other hand, TBP occupancy at the sterol repressor element 1 (site) site, further upstream was enhanced in the presence of expanded polyQ variants (Fig. 4C, upper).