We have demonstrated that synthetic cytotoxicity could be a useful strategy for expanding the sensitivity of certain tumors to DNA-damaging therapeutics.
Rolling/crawling neutrophils, monocytes and innate-like lymphocytes, besides being directly activated by the original inflammatory stimuli, recognize the changes on the vessel cell surface, and in turn generate signals that expand the sensitivity of blood vessels [ 6].
In the present study through the application of high resolution DNA array and high throughput DNA sequencing technologies, we have considerably expanded the range and sensitivity of a nascent DNA enrichment assay used to determine the position of putative origins for DNA replication in about 1% of the human genome.
The sensitivity of expanded 5-week old rosettes to Methyl viologen (MV -induced photo-oxidative stress was determined by gently spraying the plants with 50 μM MV at the end of the dark period as described in Kangasjärvi et al. [ 32].
The first sensitivity analysis expanded the definition of variceal haemorrhage, and this reduced the magnitude of the association slightly, but the comparison of most to least deprived quintiles still showed a significant difference (RR 2.60, 95% CI 2.44 to 2.76).
Selectively surveying the memory B-cell compartment also may have increased the sensitivity of detection of expanded clones, as expanded clones are readily recovered from circulating PBs in vaccinated individuals with intact immune systems [ 44].
19 In a sensitivity analysis, we expanded the definition of diabetes to include any prescription for a diabetes drug or blood glucose test strips.
We have expanded the series of experiments examining PARP inhibitor sensitivity in this mouse organoid model.
We have now expanded the series of experiments examining PARP inhibitor sensitivity with SPOP knockdown in our model systems.
Furthermore, we validated and expanded the knowledge of the changes occurring in CI sensitive or tolerant fruit, by providing strong evidence of their correlation to sensitivity in a greater range of sensitivity/tolerance.
