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Aggarwala, V. & Voight, B. F. An expanded sequence context model broadly explains variability in polymorphism levels across the human genome.
The expanded sequence of samples are then converted to a channel signal by using pulse amplitude modulation (PAM) which is superimposed on the digital modulator output for transmission.
Information on each individual site is available as a supplement to the genome sequence itself (using an expanded sequence file format that indicates the called nucleotide, coverage, quality, and other information for each position).
Using vastly expanded sequence information and substrate-defined groups, an updated CDF signature sequence was derived as well as group-specific signature sequences.
Using this expanded sequence library to build upon previous work, we present evidence supporting the existence of 22 Mamu-KIR genes, providing a framework within which to describe macaque KIRs.
The goal of the present study was to make use of the vastly expanded sequence and structural data that are currently available, to generate a comprehensive list of NISE and to obtain insights into the evolution of alternative solutions for the same reaction through comparison of the phyletic patterns of their distribution.
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While the 178-minute theatrical cut moves more swiftly and surely, the "extended edition" prepared by Mr. Jackson for this release (as well as the gift set) is impressive in its own right, adding 30 minutes of new and expanded sequences.
For PSSM generation for those expanded sequences, PSI-BLAST (with the option of –h 10−6) was run again.
Expanded sequencing of previously characterized mth variants has revealed high polymorphism in the 5' and 3' mth UTR, and the potential functional impact of these polymorphisms on expression level is currently being explored.
For example, Vβ12 CDR3 expanded sequences of the antibody-producer protected Ao191 and Ao149 monkeys included almost all possible J segments (J1.1, J1.2, J1.4, J2.1, J2.2 and J2.3; Table S1).
Expanded sequencing from mitochondrial and nuclear genomes may prove to be more useful, although this remains to be tested.
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