Firstly, further audit is required incorporating lesion size, routine vacuuming of the cavity before deployment of marker, specific sequencing of marker films, correlation of compressed breast thickness and target depth, clinical impact of marker migration and possible development of expanding marker.
These resources can contribute to gene discovery and development of expanded molecular marker sets for breeding.
To increase the sensitivity and specificity of CA-125, this single marker could be expanded to a marker panel.
These studies suggest a progression of cell death marker activation in ETC‐abnormal fibers with ETC‐abnormal regions initially not linked to cell death markers; as the ETC abnormality progressively expands, apoptosis markers (tBid, PUMA, and cleaved caspase‐3) are observed; and finally, with the longer ETC abnormalities, necrosis markers (C5b‐9 and CD68) are observed.
As in tcf7l2 mutants, transient suppression of Wnt signaling during the period of dHb neuron generation leads to upregulation of dHbl markers in right-sided neurons, whereas in axin1 mutants in which Wnt signaling is enhanced, dHbl markers are reduced and dHbm markers expanded in a Tcf7l2-dependent manner.
In subsequent years, the linkage map was expanded with SSR markers [ 3], and more recently DArT markers [ 4], and its complex relationships with the foxtail millet and rice genomes were established [ 5].
Further progress in Atlantic salmon genomics relies on these existing maps being expanded with additional markers; in particular with Single Nucleotide Polymorphism (SNP) markers, since these are the most frequent polymorphisms in addition to being the markers of choice for high-throughput genotyping.
This process has now been expanded to 15 marker-loci, MLVA15 [11].
An expanded model with markers additional to AREG and EREG may be optimal.
Even with an expanded set of markers, there is a high rate of misclassification for half-sibs, unless the mother's profile is included [24].
