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However, some situations can lead to misinterpretations: A full mutation can show up as a diffuse smear rather than as a single enlarged band due to heterogeneous array of FMR1 alleles: such smear of expanded fragments can be very faint and easily overlooked in case of high background and/or weak signal.
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84 A partial digestion may well be mistaken for a mutated (expanded) fragment.
An HD mouse model expressing a polyQ expanded fragment of Htt encompassing exons 1 and 2 exhibited neither neurotoxic effects nor an HD phenotype, despite the presence of nuclear inclusions [ 40].
H & E-stained slides demonstrate diffuse inflammation expanding fragments of choroid, ×40 (A).
It is white to pale yellow, and usually falls off as the cap expands; fragments of the ring may often be found lying on the ground near the base of the stem.
Recent data now show that the epitope of scFv-C4 (aa 1 17 of huntingtin) is a membrane-binding amphipathic helix sufficient for targeting mitochondrial and ER membranes and necessary for triggering the aggregation of expanded huntingtin fragments [49], [66], [67].
In recent years, as science reporters and interested amateurs have turned to arXiv — and as some physics personalities have started blogs — the audience for physics has both expanded and fragmented.
Over the following days, Clark expanded this fragment into a full poem, eventually setting the words to music and giving them a melody.
This may result in an accumulation of aggregation-prone expanded ataxin-3 fragment species [ 62].
Although the plastid genome has undergone reconfiguration to a compact DNA minicircle (∼1.8 3.0 kb) with its own regulatory regions (Mungpakdee et al. 2014), the mt genome appears greatly expanded and fragmented.
Results of cluster analyses of concatenated sequences of the 7 housekeeping fragments expanded and validated the proposed typing system for all chlamydial species.
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CEO of Professional Science Editing for Scientists @ prosciediting.com