Sentence examples for expanded dose from inspiring English sources

Screening experiments were carried out in duplicate and expanded dose responses with identified leads were performed at least in triplicate.

Moreover, some cumulative myelotoxicity was observed in the 13 patients treated at the expanded dose level (Table 3b).

The irinotecan dose was further de-escalated to 110 mg m−2, and three more patients were treated at this expanded dose level.

If no additional DLT was observed at the expanded dose level (i.e., 1/6 experienced a DLT), the dose was escalated.

At an irinotecan dose level of 130 mg m−2, one of the first three patients developed neutropenic fever during course 1, and one of two additional patients treated at that expanded dose level also developed neutropenic fever during Course 1.

Leads employed in an expanded dose response are shown in bold font.

For expanded dose-response experiments, additional doxorubicin and mitoxantrone were purchased from Sigma while gemcitabine, mithramycin, and thioTEPA were obtained through the NCI/NIH Developmental Therapeutic Program.

The phase I trials of gefitinib were unusual in using expanded dosing cohorts so as to provide early opportunity for investigation of end points other than simply the MTD.

One patient had febrile neutropenia grade 3, neutropenia grade 4, leukocytopenia grade 3 and thrombocytopenia grade 3 and the other patient had febrile neutropenia grade 4, leukocytopenia grade 4, thrombocytopenia grade 3 and neutropenia grade 4. Because of safety reasons, it was decided not to further expand dose level 6 and this dose level was established as the MTD.

The role of biologic therapies in the treatment of rheumatoid arthritis has expanded, but dosing patterns in the first versus subsequent lines of therapy have not been thoroughly explored.

Where specific toxicities were not considered to be drug related, dose escalation was continued without expanding the dose level.