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RE for some rate constants were over 50% and the 95% confidence interval was significantly expanded (data not shown).
This is supported by the finding that some members (Rv1361c/PPE19, Rv3135/PPE50 and Rv3136/PPE51) of the PPE sublineage IV (PPE-SVP subfamily) contain isolated MPTR-like repeats, suggesting the existence of a common progenitor gene from which the PPE-MPTR subfamily expanded (data not shown).
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Higher charge states (8+, 9+, and 10+) were also observed for this more expanded PagP conformation (data not shown).
Unlike yeast prion proteins and human Huntingtin, the aggregated proteins in our data-sets were neither rich in glutamine and asparagine (Fig. 3), nor did they have expanded glutamine repeats (data not shown).
However, we found that endothelial cells, and perhaps other islet cell subsets, markedly expanded during insulinoma formation (data not shown), which accounts for the increased BrdU incorporation present in non-endocrine islet cells (Figure 2, lower panel, lower right quadrants).
All the frequencies of helper (CD4-positive) T cells expanded were over 97% (data not shown).
We analyzed CD27 and CD357 (Watts, 2005) and confirmed reduced expression of these stimulatory receptors on expanded CD8+ T cells (data not shown).
In preliminary experiments IL-15 alone (but not IL-2 or IL-7), at an optimum concentration of 50 ng/mL, preferentially expanded IL-10 secreting IL-10 secreting shown).
21 FoxP3+CD4+ Treg cells are found in the naïve liver, but do not significantly expand after Ad infection (data not shown).
Similar proportions of sexually active circumcised and uncircumcised men – approximately one in 10 – agreed or agreed strongly that they had avoided sex in the past year because of sexual difficulties (either their own or their partner's), a finding that persisted when the denominator was expanded to include all men (data not shown).
Mulan and zPICTURE also detected this fragmentation of the rodent sequence (Fig. 1A and data not shown), expanding their extension through the use of a gap-permitted alignment algorithm.
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