Thus, PSA appears to play a role in clearance of both expanded and normal length huntingtin exon 1.
Also, in recent studies on HD degradation, rapid and complete clearance of polyQ expanded huntingtin in neuronal cells and in vitro was shown [ 184] and dynamic and reversible recruitment of proteasomal subunits into inclusion bodies was observed in living cells [ 185].
To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded volume of distribution or increased clearance.
The company has also been expanding its rights-clearance service — which involves sorting out the question of who owns, say, an image or a video clip, and how much should be paid for its use.
Support pending Congressional legislation is pending which would expand foreign pre-clearance operations to 38 countries which participate in the U.S. Visa Waiver Program.
The Obama administration is also seeking to expand a "pre-clearance program" in foreign airports to allow American border officials to collect and screen biometric information, such as fingerprints, before visa waiver travelers can board airplanes to the US.
There is often an expanded apparent volume of distribution and increased clearance resulting in lower drug exposure which contributes to higher treatment failure rates.
Amiodarone has previously been found to reduce the accumulation of expanded polyglutamine aggregates [27] and to enhance the clearance of mutant huntingtin and A53T α-synuclein in human cells [28], likely through the stimulation of autophagy.
The use of in vitro and in vivo extrapolation methods in early drug discovery has expanded in an effort to provide information on drug clearance and potential drug drug interactions earlier in development.
The transhumance corridor delimited by the Waza Logone Project in the 1990s, for example, is still there, but fields have slowly expanded and now there is no longer the legally required clearance of 25 m on each side.
