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New instruments allow volumetric effects in biochemical systems to be evaluated calorimetrically and to substantially expand the throughput of differential scanning calorimetry measurements in drug discovery and other high-throughput applications.
Although larger-scale liquid-handling platforms have generally not made their way into the average academic or clinical laboratory, such workstations are becoming more commonplace at university and hospital core facilities, giving researchers of even modest means and manpower the capability to considerably expand the throughput of their research.
Chevron and its partners are looking to invest an additional $5.4 billion to expand the throughput of the pipeline to 1.4 million bbl/day over the coming years to accommodate increased production and TCO's output.
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Our experiment suggests that by expanding the throughput using microfluidic devices integrated with FCCS, both of which can be achieved practically, we should be able to detect single virus particle in human body fluids in the near future.
Expanding the throughput of genetic and biochemical assays holds great potential for exploring biodiversity in environments where chitin degradation is known to occur.
To incorporate the error control schemes into our throughput equation, we expand the general throughput equation by including the error rate.
Therefore, the potential exists to expand the applications of high-throughput MS techniques for the comprehensive analysis of environmental exposures, ranging from the characterization of ecotoxicologic effects to the epidemiologic analysis of chemical exposures (Dowling and Sheehan 2006; Sheehan 2007).
Advances in instrumentation, pulse sequences, isotopic labeling strategies, and the development of competition experiments support the study of higher molecular weight protein targets, facilitate higher-throughput and expand the range of binding affinities that can be evaluated, enhancing the utility of NMR for identifying and characterizing potential therapeutics to druggable protein targets.
Future studies using the VEM approach can incorporate high-throughput sequencing, expand the geographical range and frequency of sampling, and investigate both DNA and RNA viruses.
Thus, although advances in high-throughput sequencing expand the bounds of viral sequence space, these data sets are dominated by uncharacterized sequences (usually 60 95%), termed 'viral dark matter' (Reyes et al., 2012; Youle et al., 2012; Mizuno et al., 2013; Brum and Sullivan, 2015).
A second recent paper used genome editing to create an assay for high throughput screening to expand the targets for drug discovery in CMT1A.
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