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At the same time, surface functional groups could enhance the wettability and expand the accessible surface area of electrode materials [16].
New chemical methodology can also allow the synthesis of isologous structures, such as the carbo- and sila-rhodamines, which expand the accessible chemical and spectral properties available to established dye scaffolds.
To expand the accessible phenomenological range, we therefore expand an electrostatic model recently proposed by Amsalem et al. (102) Going beyond the original work, we treat the metal substrate as a finite, planar, and regular grid of n × m pointlike adsorption sites at an intersite distance d.
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12 We have shown that the introduction of benzene probe molecules into MD simulations considerably expands the accessible conformational space of the flexible PBD hydrophobic pocket.
Hence, expanding the accessible side-chain conformation space by incorporating an extended rotamer library or by allowing continuous flexible rotamers (Georgiev et al., 2008) may prove important for further improving the algorithm's predictions.
A second intermediate, 9-formylminocycline 5, further expanded the accessible chemical diversity of the AMCs and, together with compound 4, provided the necessary starting materials to generate a large number of diverse AMCs in good yield to support optimization of the activity, efficacy, and pharmacokinetics of the AMCs.
By tolerating growth-neutral variability, a more relaxed metabolic regulation would expand the range of accessible individual phenotypes.
Yet in the model developed here, we suggest that restricted pleiotropy emerges to expand the range of accessible combinations of phenotypes.
These modifications greatly expand the repertoire of targets accessible to aptamers.
However, analogous reactions that result in three-carbon annulation are currently underdeveloped,[ 6] and addressing this shortcoming would expand the range of products accessible using C H functionalization/oxidative annulation chemistry.
Interestingly, the three cellulosomal catalytic domains are found alternately projected outward from the CipA scaffold in opposite directions, in an arrangement that could expand the area of the substrate accessible to the catalytic domains.
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