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More specifically, the mathematical model used here represents 2 main biological assumptions: First, that CD4+CD25+Foxp3+ cells may expand independently (it should be noted that it is known that regulatory T cells, although usually anergic, may nonetheless expand in the proper milieu of cytokines).
The branched tumor evolution model states that different tumor cells acquire different mutations over time, and that multiple clones can expand independently within the tumor [ 2, 3].
Such a high level of intra-tumor heterogeneity implied that the regions diverged early during tumor evolution and continued to expand independently, following a branched evolution pattern.
Since each bellows unit can expand independently, when one unit reaches the limiter, air flow and motion will transfer to a path of lesser resistance in other units that may still be free to expand.
It may be significant that the Foxp3-expressing population is only one of the players in the system, and we cannot yet distinguish whether 'natural' and 'adaptive' Treg expand independently in the context of this infection, or the evolution of the adaptive phenotype is dependent upon the pre-existing natural Treg population.
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Phylogenetic analysis of c6ast family genes in H. comes, platyfish and other fishes showed that H. comes pastn genes and platyfish c6ast genes form separate clades (Fig. 4b), indicating that they have expanded independently in the two lineages.
A simple thermodynamic two-state model along with the experimental results proposes that polymer chains are expanded independently of the polymer fluid interactions to further change solvent density fluctuations around the polymer chains, thereby lowering the free energy of the polymer/SCF systems.
The company attributed hefty premix sales to brand recognition, raised feed prices and expanded independently owned chain-store sales.
The Sox group B expanded independently in the genomes of the vertebrates and arthropods via different trajectories.
The two repeats have expanded independently, so we are not even sure if the sequences are truly homologous, even though the alignment score is 160 bits.
We therefore carried out further analysis into whether the mouse and rat Mup gene repertoires expanded independently, after the rodent species diverged.
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