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Although transcription-induced chimeras can function to (1) expand functional protein diversity, (2) alter transcriptional regulation, (3) inhibit transcription of the two participating genes, or (4) inhibit transcription of putative functional intergenic sequences (such as small miRNA sequences), the mechanism regulating its occurrence remains elusive [ 2].
It can expand functional diversity and enable applications ranging from biocatalysis, biosensing and even therapy.
The ability of the DC matrix to preserve adipocyte-related markers and functions of MSCs following extensive ex vivo expansion represents a novel culture technique to expand functional adipogenic progenitors for tissue engineering applications.
In our study, a genetically modified K562 cell line with surface expression of 4-1BBL and MICA was constructed to expand functional NK cells in vitro for further adoptive immunotherapy against cancer.
Overall, these results suggest that CTSK knock-down may provide a feasible way to expand functional human chondrocytes in vitro for engineering good quality human cartilage and thus may have its great potential in the clinical translation of engineered cartilage in the future, given the fact that biosafe RNA interference techniques are already available.
We are thrilled to announce that Prof. Matt Becker will join the Department to further expand functional biomaterials at Duke!
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Retro-Diels-Alder reaction (rDA) has been widely used as a common modification approach for expanding functional applications of polymers.
The 2013 Standard is an update from the previous API/NPRA SRA Methodology (2004) and focuses on expanding functional utility without changing the basic methodology.
The map also uncovers significant interconnectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots" of the genomic revolution.
The optimized method exhibit enhanced substrate scope and expanded functional group compatibility allowing the synthesis of bundle of novel thiophene based structures in significant yields.
Here, we review the recent progress that resulted specifically from exome sequencing and emphasize the need for rigorous statistical evaluation of the expanding data sets, as well as expanded functional analysis of implicated proteins and mutations.
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