Therefore, although rhBMP-2 appears to be a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation, dose and carrier optimization are being profoundly studied to expand its efficacy, use, and clinical application [ 74].
In fact in a phase II trial, ATO alone was inefficient in the treatment of HCC, suggesting that strategies to enhance and expand its therapeutic efficacy are needed.
The increased ability to perform CHMI studies in malaria endemic countries would expand international capacity for efficacy testing of vaccine candidates and allow earlier assessment of vaccine efficacy in target populations.
Our designed triepitopic constructs have the potential to enhance the efficacy and expand the scope of EGFR-directed therapies, and our multiepitopic may be readily applied to other receptor targets to formulate a new class of antibody-based therapeutics.
Moreover, the created surfaces also show excellent resistivity to ice water, boiling water, high temperature, organic solvent and oil contamination, which could expand their usefulness and efficacy in harsh conditions.
The present phase-II trial sought to expand the safety and efficacy data obtained in the dose-finding trial.
As CAM research continues to expand beyond tightly controlled efficacy trials to more practice-based effectiveness trials, it is essential to have a better understanding of how CAM practitioners are organized and function in the real world of CAM practice.
Thus although switching signalling cascades activated by Met mutants leads to comparable efficacy to expand the Pea3 expression domain in the context of two functional copies of Pea3, the signalling routes employed by the Met signalling variants are differentially sensitive to Pea3 gene dosage reduction: the Met2S route is sensitive, whereas the Met2P is not.
According to self-efficacy theory, "mastery experiences" are the most influential means of expanding one's efficacy because they show most clearly how people can bring together the things they need to succeed.
The Chronic migraine OnabotulinuMtoxinA Prolonged Efficacy open Label (COMPEL NCT015168922) Study was designed to expand on the current 56-week efficacy and safety data by evaluating the long-term efficacy and safety of onabotulinumtoxinA for prevention of headache in those with CM.
