Sentence examples for exogenous reporter from inspiring English sources

Unfortunately, they are not easily translated into the clinic, necessitating the need for exogenous reporter probes.

Interestingly, the analogous dependence of timing of both cAMP and GR that exists for ACTH secretion [17], which obviously is not linked to the activity of the exogenous reporter plasmid, suggests that the phenomenon of time-dependence occurs at multiple genes.

This model might explain why disruption of cofactor-activated phosphorylation impairs the anti-neurogenic activity of Gro/TLE1, which involves regulation of endogenous promoter/enhancer elements, but does not detectably perturb Gro/TLE1-mediated transcriptional repression of exogenous reporter genes, which are unlikely to acquire a true chromatin-like structure in transfected cells.

Research into DSBR exploits rare-cutting endonucleases to cleave exogenous reporter constructs integrated into the genome.

This method targets an exogenous reporter gene from a transfected vector, minimizing the concern of pre-synthesized endogenous proteins.

Exogenous reporter genes can affect the dynamics of regulatory genes in synthetic genetic circuits in two ways.

The normalisation failures observed for abundant exogenous reporter-transcripts probably reflected the results concerning endogenous transcripts: the coexistence of a majority of singlet contigs (68%) with a few, very deep contigs.

Finally, using both endogenous HPRT and exogenous reporters, we validate novel cell cycle phase-specific I-SceI derivatives for investigating cell cycle variations in DSBR.

While the utility of exogenous reporters has been questioned because of the lack of chromosomal structure, this does not appear to a major issue for GR-regulated gene induction.

We examined the transcriptional activity of the Alk4* induced P-Smad2/3 in the TAG1 system using an exogenous luciferase reporter 0.9-P1, whish is driven by the Smad2 regulated promoter of Pitx2 gene [19] (Figure 1D) in transient transfection assays.

Using both an exogenous recombinant reporter construct and endogenous gene product we have demonstrated that M3 mACh receptor activation results in an increase in gene transcription.