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Conversely, exogenous glucagon can increase energy expenditure.
For systemic administration of exogenous glucagon, mice were injected in the peritoneal cavity with human glucagon (1 mg/kg body weight) or saline after 3 h of fasting.
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Exendin-4, an exogenous glucagon-like peptide-1 receptor (GLP-1R) agonist, protects the heart from ischemia/reperfusion injury.
Exogenous glucagon-like peptide-2 (or its analogues) may be a potential therapy because of its intestinotropic properties.
The effects of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrients was studied in critically ill patients.
In healthy patients and those with type 2 diabetes, exogenous glucagon-like peptide-1 (GLP-1) decreases blood glucose by suppressing glucagon, stimulating insulin and slowing gastric emptying.
Previous studies have shown beneficial effects of exogenous glucagon-like peptide (GLP -1 on GLP -1mia in critically ill patients, a phenonenon also seen in patients with type 2 diabetes.
The purpose of this study was to determine the effects of exogenous glucagon-like peptide 1 (GLP-1) on the glycaemic response to enteral nutrition in nondiabetic, critically ill patients.
In this issue of Diabetes Care, Sathananthan et al. (1) report differences in the insulinotropic response to exogenous glucagon-like peptide-1 (GLP-1) in healthy volunteers, depending on the presence or absence of certain common polymorphisms of the GLP-1 receptor gene.
Based on these results, antidiabetic agents that preserve, maintain, or improve β-cell function, such as exogenous insulin, glucagon-like peptide 1 analogs, dipeptidyl-peptidase 4 inhibitors, and thiazolidinediones (39), may merit attention for the vulnerable (40) transplant population and early posttransplant period.
With exogenous GLP-1, glucagon secretion from α cells was suppressed in the presence of hyperglycemia and euglycemia but not hypoglycemia.
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