Sentence examples for exogenous expansion from inspiring English sources

In addition, the intrinsic resistance of Tregs to exogenous expansion and the probability that a large number of Tregs will be required to enhance peripheral tolerance in humans makes it desirable to isolate a larger Tregs subset for exogenous expansion.

We found that exogenous expansion of CD4+CD25+ cells produced a population containing 70 85% CD4+Foxp3+Tregs.

This enhanced Treg suppressor function following exogenous expansion is consistent with prior reports of Treg function in other murine models and with our previous findings with the CD4+CD25+CD62LHITreg fraction in B/W mice[24], [31].

A total of two separate cell sorts, exogenous expansion, and adoptive transfers were preformed in order to generate sufficient cells to treat the target of at least 20 mice per arm.

We demonstrate that exogenous expansion and transfer of Tregs contained within the population of CD4+CD25+ T cells suppresses the onset of glomerulonephritis and prolongs survival in a murine model of lupus.

However, consistent with prior reports in other mouse strains[29], [31] there was a marked increase in both Foxp3+ and CTLA-4 expression in B/W Tregs following exogenous expansion (Figure 2C D, p<0.01 for both, 3 6 mice per group).

Vaporization and expansion of exogenous water is a fundamental process driving phreatic eruptions (e.g., Rouwet et al. 2014).

The Internet remains in a persistent state of flux, subject to changes in various exogenous factors, e.g., geographic expansion of ASes, new entrants in the connectivity market, removal of nodes from the network owing to bankruptcies, changes in technology, etc.

Complete Tcf3 deficiency greatly reduced differentiation and allowed ES cell expansion without exogenous LIF, even at clonal density.

While these results demonstrate a lower G-CSF binding and expansion to exogenous G-CSF by leukocytes expressing the Sle2c2 Cfs3r allele, evidence of greater G-CSFR signaling in leukocytes expressing the Sle2c2 Cfs3r allele was also observed.

In zebrafish, exogenous RA led to expansion of both exo- and endocrine cells, while in Xenopus embryos as well as cultured mouse embryonic pancreatic rudiments, exogenous RA led to an expansion of the endocrine cell population at the expense of the exocrine cells in the dorsal pancreas [ 129, 141, 142].