We distinguish between an endogenous development in which the driving forces mainly come from inside the community and an exogenous development, in which the development was driven by actors from outside the community.
Indeed, when the mutant strains were given exogenous DNA, biofilm development was strongly increased in R36APΔsvl and R36APΔlytA (Fig. 4B).
Mutants deficient in BR or BR signaling have shorter roots than WT and in the presence of supraoptimal exogenous BR, root development can be severely impaired [ 34- 36].
Reproductive tissues of male mice appear to be especially sensitive to the toxicological effects of DES (McLachlan et al. 1975; Prins 1992; Prins et al. 2001), and presumably other exogenous estrogens, throughout development.
Acting early during development, exogenous estrogenic compounds may also play a role in producing modifications during key stages of ontogeny in mammals [ 5], having consequences on population traits such as mate preference [ 19] or life-history traits such as sexual maturation [ 20].
The brain is the major site of Sia display and has been suggested to depend on an exogenous supply during growth and development [10], [11].
Pellicle biofilms of B. subtilis do not contain natively produced norspermidine at any stage of development, and exogenous norspermidine is not inhibitory to pellicle development until a concentration 10-fold higher than reported by Kolodkin-Gal et al.
These results as well collaborates with the findings of a study carried out by Beck et al. (2000) on the impact of financial development on economic growth in which it was discovered that there exist a positive link between the exogenous component of financial development and economic growth.
Recent reports have indicated that ESCs or differentiating ESC-secreted proteins may affect the growth and development of exogenous cells, such as cell migration and myogenesis (Ngangan et al., 2014; Yousef et al., 2014).
It is likely that a better insight into epigenetic regulation of B cell tolerance will lead to development of gene-specific therapeutic approaches that optimize host defense mechanisms to exogenous threats, while preventing development and/or progression of autoimmune inflammatory diseases.
