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In view of our own results, we speculate that LT-HSCs may be pushed toward differentiation at the expense of self-renewal if they shorten or bypass phases of the cell cycle other than G0 exit, undergo several rounds of division without returning to G0, or show imbalances in key differentiation genes.
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The fuel-rich annular ring close to the nozzle exit undergoes premixed combustion, but once oxygen is depleted inside the annular ring, diffusion flames are established on both sides of it due to excess fuel emerging from the premixed zone.
Thirdly, Xenopus primary neurons require cell cycle exit to undergo differentiation (Vernon et al., 2003), whereas differentiation of AVNA cells show a reduced requirement for this (Fig. 3).
Skeletal muscle displays a robust regenerative response upon injury where muscle stem cells (satellite cells) exit quiescence, undergo activation, proliferation and fuse to form newly regenerating myofibers [ 1, 2].
During mitotic exit, Ser undergoes dephosphorylation by the phosphatase Cdc14A.
These decisions are even harder for students who drop out, since they do not typically undergo exit counseling.
Undifferentiated cells exiting the MF undergo a second round of cell proliferation, which includes a single round of synchronized mitosis (second mitotic wave).
P27Kip1 arrests cells in G1 phase, and allows cells to exit cell cycle and undergo differentiation [36], [37], [38].
These results indicate that Wnt/β-catenin signaling can affect the rate at which cells divide in the proliferating chondrocyte pool, but only PTHrP signaling controls the brake that determines when chondrocytes exit cell cycle to undergo hypertrophy.
A regional specificity of action is evident in that forebrain progenitors that fail to exit the cell cycle undergo apoptosis.
Patients in each trial arm will undergo standard exit site and other management, as per the haemodialysis unit protocol.
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