However, it is also possible that the genetic variant is merely a confounding factor, and that no functional relation exists between variance in DNA methylation and variation in metabolic traits.
In most cases when multiple predictors in a regression model are correlated with one another, there exists shared variance of the dependent variable among those correlated predictors.
The model was checked for multicollinearity and no problem existed (all variance inflation factors <2).
Since a drastic relationship between mean and variance exists for sheep prolificacy [ 16], the comparison of variances on the observed scale was not direct but based on the predicted distribution of LS for each genotype through a back transformation to the observable scale using the estimated thresholds for each genotype (τ ^ i, i = + +, L + ).
However, if genetic heterogeneity of variance exists, Mendelian sampling deviations are also expected to affect the level of residual variance and an animal model for the variance would be theoretically more correct.
Population genetic evidence suggests that most worldwide genetic variance in humans is seen within populations and only a small percentage of variance exists between populations or between countries.
For example, PCAIMs are chosen to represent the underlying variance of all samples; for our data set, a large part of this variance exists between central European populations and outlying populations (eg, Finland and Spain).
Consequently, there exists a feasible variance allotment to sources in such that the -sensor cannot waste any of the variance allotted to it.
Heterogeneity of variance was not sensitive to Box-Cox transformations of phenotypes, which implies that heterogeneity of variance exists beyond what would be expected from simple scaling effects.
The individual-level variance components and H, estimated by REML, are robust to lack of balance and indicate that significant genetic variance exists to explore with QTL mapping.
