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Unlike other clinical trials, we did not select those treated with foot orthoses on the basis of foot posture (for example, excessive pronation 22), largely because no valid method currently exists to identify a priori those who may benefit from foot orthoses.
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31 This means, if mechanisms exist to identify a vulnerable person, mechanisms and services also need to be available so that they can be referred for appropriate help.
Since no controlled clinical trials exist to identify an optimal antibiotic regimen, decisions must be based on known in vitro sensitivities together with anecdotal clinical evidence.
Experts are most useful when a system exists to identify the most truly knowledgeable — a system that often resembles a market.
This in turn, means that the researcher needs detailed knowledge on the phenomena and the abstract relationship that exists to identify items consistent with a theory.
Unfortunately there are few examples that meet both requirements and an urgent need therefore exists to identify those traits that have a plausible chance of meeting these requirements.
Consequently, a need exists to identify new parasite targets for therapeutic intervention and the nematode intestine provides a tissue to investigate for this purpose.
Therefore, a need exists to identify pathways that can regulate this process.
Because of the extensive environmental contamination with phthalates, a need exists to identify the most important sources and pathways of exposure [ National Research Council NRCC) 2006].
Since a vaccine is not available, an urgent need exists to identify novel targets for the development of new chemotherapeutics [17].
A need also exists to identify the most useful tools for monitoring these changes.
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