A possibility exists that the differences between random control and disease-associated genes are not objective, but arise accidentally due to a particular composition of the integrated panel.
Nevertheless in this study there are no data on subjects who reached extreme longevity, such as centenarians (mean age of the subjects was around 60 years), and the possibility exists that the differences observed were due to an altered health status, as an association of some of these markers with hypertension and Type 2 Diabetes was reported.
A formal possibility exists that the observed differences between the evolutionary rates of duplicates and singletons were due solely to the presence of extremely rapidly evolving gene pairs of potentially mis-identified orthologs (Methods; Figure 5).
Cardinal differences between animal models and patients exist that may contribute to the differences in study outcomes [ 27, 28].
Various parameter optimization methods exist that minimize the difference between experimental data and corresponding model simulations, e.g., trust-region optimization methods, simulated annealing, and genetic algorithms [ 31].
However, local differences may exist that would introduce uncertainties into the difference between chemotherapy and hormone therapy costs.
Therefore, the possibility exists that no difference was found because the observers encoded and accessed the memory items by their conjunctions, rather than by the currently task-relevant property (i.e., color or identity) only.
The possibility exists that some of the differences in barriers or motivators occurred because of differences in characteristics of the cases and controls.
Many possible factors exist that might account for the observed ethnic differences in severe maternal mortality.
An important condition to the ionic bond to exist is that the difference in electronegativity between the atoms involved in the bond must be significant.
The equal possibility exists, however, that the differences in the methodology employed in our study compared to others may have had an impact on the resulting data.
