Our findings are generally in good agreement with previous in vitro characterizations, and what contradictions exist are likely due to methodological differences.
The difference that does exist is likely due to the fact that the GENCODE geneset is genome-centric whereas the RefSeq geneset is transcript-centric; the latter can also include loci that cannot be mapped to the current reference genome (GRCh37).
Future work will use elementary mode analysis [ 33] to determine if multiple pathways that lead to the same optimum exist, which is highly likely due to the size and complexity of the network.
Despite high interest in a structure of the kinase domain, no such structure exists for any TOR, which is likely due to technical difficulties in expressing this domain for structural studies.
Also, as already outlined, significant population differentiation among host plants exists in B. cinerea (Fournier and Giraud 2008), likely due to specialization to the host, but with significant gene flow.
The only unusual trend exists for those with no High School diploma; this is likely due to the smaller sample sizes (and larger errors) among respondents in this group.
A high level of variability exists in epidemiologic reports of incidence and prevalence in IPF, most likely due to differences in diagnostic testing and case definition, as well as differences in study populations and study design [ 4, 5, 11].
The association between "gilberts disease" and "family history of colon cancer" (OR 26.5, p = 2.5×10−4) likely exists due to a cancer trial protocol at our institution asking clinicians to monitor bilirubin levels but has exceptions for patients with Gilberts.
These differences are most likely due to residual system alignment offsets that exist between the light delivery and collection arms of the AOSLO; such system offsets are technically difficult to eliminate.
Our results show that substantial transcriptomic differences exist between embryonic mammary cells and postnatal mammary cells, which are most likely due to a unique microenvironment and their immature state.
