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Calais has a long tradition in lacemaking; although this industry still exists, its importance has much diminished.
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As with NTIRE or ECT, the need for accurate needle placement exists and its importance has been evaluated.
For example, a single biopsy may not be representative of the genetic composition of the cancer, leading to inappropriate choice of treatment; and if a rare subclone exists, what is its importance for therapy?
Exceptionalism exists anyway; partisanship increases its importance.
However, surprisingly few studies investigate this mechanism experimentally and no quantitative evidence of its importance exists.
As few premonitory symptoms for fracture exist, it is of critical importance that physicians effectively and efficiently identify individuals at increased fracture risk.
Despite its importance, little quantitative information exists on the horizontal and vertical variation of soil profiles, especially in natural landscapes that are unaffected by soil erosion.
However, it is unclear what relationship exists between personal importance of exercise and fears of re-injury and whether, over time, higher exercise importance counteracts fears of re-injury and is associated with greater activity levels.
However, given its importance in flotation, there existed no mathematical relationship linking bubble size created in flotation machines to the key process variable of fluid viscosity.
It should be noted that some controversy exists regarding the importance of face validity, particularly face validity for the defining symptoms of schizophrenia, with some arguing that it is of primary importance [ 3], and others that it is the least important type of validity and perhaps not important at all [ 4].
The genesis of fragipan is still unclear, but a general agreement exists on the importance of wet-dry cycles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com