No definitive approach exists for identifying and filtering erroneous or unwanted data, yet inappropriate filtering can create artifacts or eliminate/distort critical features.
However, it can only be successfully applied if some prior knowledge exists for identifying seed regions.
While less clear support exists for identifying more ancient amino acids, this set most likely consists of Gly, Thr, Pro, and possibly Ala and Val.
However, no similar resource exists for identifying co-occurrence TFBSs in a group of mammalian promoters.
Others claimed that no criterion exists for identifying good performance, despite the quantitative indicators mentioned above.
Because of the high level of conservation, for these loci, little information exists for identifying relationships among lineages.
Less evidence exists for identifying the strains as M. marseillense because of the clear divergence in the genes investigated, other than 16S rRNA.
In contrast, copy number alterations in human cancer can be very large, encompassing many genes, and no systematic approach currently exists for identifying the critical genes within these regions [290].
At present, though theoretical and computational tools exist for analyzing the filtering properties of a given network, as pointed out by Rao et al. in [ 1], no good theory exists for identifying all possible systematic mechanisms that generate robust networks to compensate biochemical process delays and to attenuate molecular noises simultaneously.
There may not be a coexpression threshold that can indicate the molecular interactions of two genes, but a threshold exists for identifying the strongly coexpressed gene pairs to optimally differentiate the normal and the disease groups in terms of the functional linkages.
