ILK has a possible upstream role in ERK1/2 activation [ 16, 22, 23, 48], but no rational mechanisms exist for examining this regulation [ 2, 3].
Available sequence data for P. malariae are very scanty, and currently no well-established loci exist for examining genetic diversity in this species, apart from the small subunit rRNA genes (11 ).
Probabilistic methods exist for examining the types of selection, if any, on binding sites within closely related organisms - yeast species (20 million years of separation) and fly species (10 million years of separation) - however these methods require high quality alignments [ 32, 33] which are not easy to generate for the distantly related apicomplexans in our study.
Several approaches exist for examining the effect of climate change on vectorborne diseases, based either on observed relationships between climate conditions and vector development in laboratory or field studies (biological or empiric models) or on correlations between the geographic distribution of disease or vectors and climate variables (statistical models).
However, no evaluative framework exists for explicitly examining a network organized system of care in this context.
This same relationship exists for models examining the probability of meeting FV recommendations in which females (OR = 2.14, p < .05) and college educated (OR = 1.74, p < .05) participants have increased odds of meeting FV recommendations (see Table 4).
A need exists for prospective cohort studies examining the impact of smoking on HSCT outcomes.
Nadja Buus Kristensen, a PhD student and junior author of the study, said: "According to our systematic review, no convincing evidence exists for consistent effects of examined probiotics on faecal microbiota composition in healthy adults, despite probiotic products being consumed to a large extent by the general population".
No such evidence exists for any other category of flavonoids examined.
Some biologic plausibility exists for associations with the other polymorphisms examined but possibly the associations were too small to be detected.
