The results indicated that there exists a dose window for electrical isolations.
Second, we investigated whether an association exists between dose intensity and overall survival (OS).
It would also be of interest to investigate if a link exists between dose of β-alanine administered, the degree of elevation in muscle carnosine content and the magnitude of the improvement in an exercise outcome.
The coefficient α' in equations (6) and (7) can be considered as an equivalent radio-sensitivity, because it can be used to achieve same clinical results compared to more sophisticated linear – quadratic – proliferation models, as far as there exists a dose that can be considered uniform per fraction in RT.
It is also known that an inverse dose rate effect exists in that dose rates of 0.2 0.4 Gy/h can give more cell kill than dose rates in the range 0.7 1.0 Gy/h [ 15, 22].
Limited guidance exists for dosing melphalan for autologous stem cell transplantation (ASCT) in the obese patient population, because the current literature reports conflicting clinical outcomes between obese and nonobese patients.
More importantly, from the data available, it appears that a correlation exists between doses of VC which cause tumors and those that saturate metabolic or detoxifying pathways.
Furthermore, to aid practitioners, a need exists for dose-response studies to determine the optimal exercise program(s) for overweight and obese children and adolescents.
45 Thirdly, some uncertainty exists about dosing in certain clinical settings such as renal failure, old age, and concomitant intake of amiodarone, which may lead to either underdosing or overdosing given that no pharmacodynamic marker for monitoring exists.
Guidelines exist for dose adjustment of other cytotoxic drugs that are predominantly renally excreted (Kintzel and Dorr, 1995).
