For instance, if an alpha-beta hydrolase exists with a specificity for a particular hydrolytic reaction, it will only take a small modification of a TIM-barrel with a related hydrolytic activity to evolve a pair of NISE.
The presentation of information regarding jurisdiction-specific policies varies in degree of detail because 1) uneven levels of information were available regarding the intricacies of national policies and 2) there exists an inconsistent degree of specificity in the actual policies.
Normally, there exists a strong negative correlation between gene expression level and its tissue specificity [ 40].
One study performed by Laumonier and coworkers revealed that in hepatocyte nuclear factor 1 alpha (HNF1A) -mutated and inflammatory HCAs characteristic MRI patterns exist, which reach a specificity of 100%% and a sensitivity of 86.7%% [ 27].
Stenosis exists ultrasound specificity is greater than 95%.
This is also true for multigene families LIP1 LIP19 hydrolases of triacylglycerides, where there also exists chain-length specificity [ 3], although the specificities of the ALK1 ALK19 genes are not completely known.
Studies in heterologous expression systems have shown that BMP7 and BMP6 have the capacity to bind to the same type I and type II BMP receptor subunits [19], although subtleties of binding may be masked by the high concentrations achieved by over expression, potentially concealing receptor specificity that exists in a cell-specific context.
It is well-recognized that large numbers of C. perfringens will coat the damaged intestinal epithelial surface of chickens with NE [72], but little to no information exists on the specificity of this adherence.
No published data exists concerning the specificity and sensitivity or data of agreement for these ELISAs.
Although distinct classes of compounds bind to each receptor, owing to the diversity of these compounds' chemical structures, promiscuity exists in their specificity, particularly in the case of PXR and CAR [ 6, 7].
