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This study enables efficient identification of possible novel therapeutic targets and alternative indications for existing therapeutics.
Currently, the existing therapeutics revolve around non-steroidal anti-inflammatory drugs, antimalarials, steroids, immunosuppressives and biologics.
Existing therapeutics to enhance male sexual health are limited by factors that include responsiveness, adherence and adverse effects.
Targeting RAD51 is therefore an attractive strategy for treating difficult-to-treat cancers, e.g. triple negative breast cancers which are often resistant to existing therapeutics.
The paper deemed 53 papers 'landmark' studies and acknowledged from the outset that some of the data might not hold up, because papers were deliberately selected that described something completely new, such as fresh approaches to targeting cancers or alternative clinical uses for existing therapeutics.
An area of increasing interest is metabolic reprogramming, whereby drug-induced alterations in the metabolic landscape of a tumour slow tumour growth and/or increase sensitivity to existing therapeutics.
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Furthermore, these pathways contain enzymes that can be harvested as powerful biocatalysts for the synthesis of both new drugs and existing blockbuster therapeutics.
Gold nanoparticles (GNPs) are emerging as a novel tool to improve existing cancer therapeutics.
Magnetic hyperthermia is a fast emerging, non-invasive cancer treatment method which is used synergistically with the existing cancer therapeutics.
Motivated by the need for novel antimycotics that act orthogonally to existing antiergosterol therapeutics, we first sought to identify chemical compounds with whole-cell biological effects against fungi.
The next steps for each is devising the best mode of drug delivery, further drug development, and devising treatments to synergize with existing cancer therapeutics.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com