The hierarchical structure of ISA-Tab enables the representation of studies employing one or a combination of omics and other technologies, overcoming the fragmentation of the existing submission formats built for specific types of assay.
This step also serves as a error detection: if an existing entry in TANTIGEN does not match the information entered in the standardized submission form, the user is notified and prompted to determine whether the existing entry, the submission, or both are erroneous.
The former is essentially a cross-matching process, i.e. out-links are only added when they match pre-existing submissions from another source, whereas the latter includes de-novo deposition.
Programs and staff would need to learn how information from the new technologies might be incorporated in regulatory practices and decision-making processes and would also have to face possible incongruities between toxicogenomics-derived data and existing or future submissions of conventional toxicity data.
If the conclusions are not adequately supported by the existing data, the submission should be rejected.
The improvements included submission of new evidence, additional literature publications to support existing network edges, and submission of new biological edges with supporting evidence for relationships that were not represented in a network.
Existing schemas already exist that could be adapted or extended for this purpose including the Resource Specification Language (RSL m and the Job Submission Description Language (JSDL).
Equally important, GLAAD's president Neil Giuliano told me his group will accept these submissions in the existing categories, inviting the gay media to compete head-on with the mainstream media rather than in some 'gays-only' category.
Ford's submission, for its existing Transit Connect van, was viewed early on as problematic and uninspired, and some taxi officials were taken aback to see the city include the car as a finalist.
In regard to patent disclosures, only existing, relevant patents issued before submission of a paper need to be disclosed.
