Sentence examples for existing mutation from inspiring English sources

Novelties of our approach are: (1) evaluation of the fault detection capability (in terms of revealing faults in the SUC) of test sets generated based on the mutated models, and (2) superseding of the great variety of existing mutation operators by iterations and combinations of the two proposed elementary operators.

Five cMS-bearing genes identified from the genome-wide search and without existing mutation data (SFRS12IP1, MED8, ASXL1, FBXL3 and RGS12) were found to be mutated in at least 5 of 11 (45%) of the MSI-High cell lines tested.

Both of the above techniques guarantee the quality of the individual after mutation, which undoubtedly accelerates the evolution and makes the proposed adaptive Gaussian mutation operator distinct from existing mutation operators.

Later, in regard to the explanation of the origin of sexual reproduction, he offered an alternative to the existing mutation elimination explanation in the form of his Parasite Red Queen hypothesis, according to which the main goal of sexual reproduction is to create continuing genetic diversity and in this way fool parasites (or pathogens).

The workflow of our PSAAP algorithm is summarized in Figure 3. Next, both curated RET mutations (known disease association) and RET uncertain variants (VUS data) were analyzed and compared using four existing mutation prediction algorithms.

However, subject BR1427 already has an existing mutation within an HLA-matched epitope in NS2 close to the time of infection, which is unlikely to be due to T-cell pressure at this stage and may represent the transmission of a viral adaptation induced in the previous host.

As the field of genome science has advanced, Dr. Ling added, Dr. Smith's technique now holds potential for fighting certain genetically based diseases through gene therapy -- by undoing existing mutations that cause disease, in effect putting abnormal DNA sequences back to normal.

Perhaps, they mused, faulty HSP90 genes might allow existing mutations to wreak havoc.

The first is to make new ATP-competitive inhibitors that exploit binding modes that can circumvent the existing mutations.

Of note, most studies examining FLT3-ITD in cell lines, have introduced the FLT3-ITD mutation into an already transformed cell with existing mutations and alterations.

As the chemical composition and physical conditions of tissue microenvironment are complex, their change with age will impact the existing mutation-generated functional diversity through an independent stochastic component, contributing to diversification of the relative fitness of different cells in a stochastic manner (Fig. 7F).