We agree with Tafuri et al. [ 1] on the need to incorporate existing knowledge and would like to specify the potential role of population PK PD modeling.
Imagine if your options when learning to identify Quokkas were either to independently relearn the entire concept of heads, bodies, legs and fur, or to try and incorporate your existing knowledge but risk forgetting what a cat looks like.
However, the existing knowledge is very limited about Mallotus philippinensis and its different parts like steam, leaf, and fruit.
But some discoveries like that of Hubble's concerning the galaxies altered existing knowledge to the extent that we had to "unlearn" or uninstall some previously accepted fundamental concepts and substitute the distinctly new.
Innovative solutions typically come from new combinations of existing knowledge.
How can new knowledge be created from already existing knowledge?
We also need to differentiate between fundamental advances in knowledge and logical extensions of existing knowledge.
It will ensure that existing knowledge is freely available to anyone, everywhere, at any time.
Protest movies should denounce things you don't know, not prop up existing knowledge".
They analysed data and made conclusions, using existing knowledge to understand something new".
