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No impact on existing indications.
The purposes of this study were to review our experience with this procedure for trauma; to classify injury grades for both pancreatic and duodenal injuries in patients undergoing pancreaticoduodenectomy according to the American Association for the Surgery of Trauma-Organ Injury Scale for pancreatic and duodenal injury; and to validate existing indications for performance of this procedure.
INTERMACS profiles help identify ambulatory patients with advanced HF who may benefit from current mechanical support devices under existing indications.
Again, these agents were repurposed from existing indications.
The main existing indications for hyperbaric oxygenation (HBO) therapy are well known.
These new studies may not only strengthen the existing evidence base, for instance by allowing meta-analyses, but also refine the existing indications or extend them to new groups of patients.
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This refers to the possibility of including a woman into one of the existing indication categories provided by the authors before she is actually taken to the operating theater.
A second operation to perform a complementary ALND was not done in 39 of them (26%) for various reasons: age or frailty of the patient (n = 25), an already existing indication for parasternal radiotherapy due to metastases in IM SLNs (n = 5), a synchronous contralateral breast cancer with preoperatively proven lymph node metastases (n = 2), or unknown (n = 7).
(Note: This does not suggest that one million dementia patients should be treated with anti-dementives. As a matter of course, a very tight medical indication and existing contra-indications imply that only a fraction of dementia patients can be considered for drug therapy).
However, this epidemiological information might not be available when an existing indication, e.g. 2-line treatment in oncology, is further restricted leading to a new niche and therefore lacking existing epidemiology data.
In addition to assessing existing data, indications of candidate chemicals of relevance for future monitoring can be gained by evaluating production, use, and emission patterns of chemicals on the geographical scale of interest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com