In summary, our study reveals a consistent neuropathological and neurodegenerative phenotype existing in the brains of aged α-Gal A-deficient mice that is intimately associated with the disruption of the ALP.
Then NSCs become neural progenitorcells existing in the adult brain neurogenic region: the sub-ventricular zone (SVZ) and the sub-granular zone (SGZ) [ 17- 20].
Although the research is at an early stage, the finding suggests that scientists could someday recruit existing cells in the brain to repair the brain and spinal cord after a stroke, injury, or neurodegenerative disease.
BDNF is a prosurvival factor induced by cortical neurons that is necessary for survival of existing neurons in the brain as well as the growth and differentiation of new neurons and synapses (31, 32).
Third, non-angiogenic NSCLCs (Pezzella et al, 1997) that show an alveolar pattern of growth may metastasize, and do not merely co-opt existing vasculature in the brain, but instead develop a more angiogenic phenotype with haphazardly arranged vessels.
In addition, our data supports the idea that latent progenitor reservoirs existing in neurogenic regions of the brain have a diminished capacity for supporting neurogenesis in AD.
Two iNPH patients with higher cortical PIB retention had the lowest levels of CSF Aβ42, indicating that PIB retention in iNPH would not reflect a simple delay in the clearance of PIB but its binding to real- existing Aβ amyloid in the brain.
Tissue should be collected from a proper cohort of animals at the time when treatment is initiated to determine whether the treatment reduced pre-existing pathology in the brain or simply slowed its age-associated accumulation.
In this scenario, the dynamic range in some subcortical loops and the efficacy of ascending and descending excitation can remain largely intact, despite existing in a significantly inactivated brain.
Since drugs alter existing levels of activity in the brain, that takes a toll on cells over time, exhausting and degrading them.
