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Existing immune strategies are mainly designed for static networks, which become ineffective for temporal networks.
The concept of existing immune memory has also been modified by using the elitist mechanism.
Different from the existing immune optimization methods, NSIOA constantly removes the worst solutions to get the optimal solution.
Reversal of existing immune dysfunction(s) and normalization of lymphocyte homeostasis in patients with cancer needs to be a part of future cancer immunotherapy.
The idea is to accurately read the inherent drawbacks of existing immune algorithms (IAs) and propose new techniques to resolve them.
Reasoning that the selected T cells, to be effective, would have to make up the bulk of cells in each patient's immune system, the team administered chemotherapy to the patients to temporarily wipe out substantial numbers of existing immune cells.
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15 Both CD4+ T Cells and MHC Class II activity have been implicated in sarcoidosis, and these interactions support a role for ZNF592 in the existing immune-based genetic understanding of the systemic disease.
We have previously demonstrated that by selectively coating tumor cells with immunodominant foreign immunogenic CD8+ T cell peptide(s) recognized by pre-existing immunity, immune tolerance can be bypassed and pre-existing antigen-specific immunity was able to control the tumor [ 4].
Thus, assessment of the impact of pre-existing immunity on immune protection and alternative vaccination strategies may be needed for successful use of many adenovirus-based vaccines.
Broadly, this encompasses treatments requiring the strong induction of immune responses, both humoral and cell mediated, or the down modulation of an existing pathological immune response, either through immune deviation or suppression.
Adaptive immunity developed within an existing innate immune system to more effectively eradicate foreign antigens, whether from pathogens, malignant cells, or microbial toxins, such that repeated stimulations with foreign antigens are more efficiently excluded.
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