This scenario is analogous to both annotating proteins of unknown function (hypotheticals) and analyzing existing functional annotations created using electronic methods, for proteins currently residing in the RefSeq and Uniprot databases.
We used methanogenesis pathway as a case study in order to show how enzymes with new functions can be formed from elementary functions and via reutilization of already existing functional domains.
Two kinds of motifs were used in this paper: one with biological functions obtained by searching the existing functional motif dataset PROSITE [ 31] and the other with statistically significant motifs searched by MEME (http://meme.nbcr.net/meme/cgi-bin/meme.cgi).cgi
These results highlight the need for re-appraisal of existing functional data to inform the current protein function studies on these two important toxin pathways.
We feel this task is different from cases where the function prediction is "de novo", without using existing functional annotation.
It has been argued that most brain functions commonly cited as integrative merely sustain an existing functional integration, suggesting that the brain is more an enhancer than an indispensable integrator of bodily functions (Shewmon 2001).
Elements of a degenerate system are free to functionally diverge over evolutionary time without compromising the existing functional output.
In this paper, three existing functional reasoning models are reviewed in this perspective.
Worldwide research efforts are underway to find new applications for ferrites in addition to improving their existing functional properties.
Variants were classified for functional impact based on intragenic position, existing functional data, sequence, and structural analysis.
