The DUB ataxin 3 plays an important role here in remodelling the Ub-tags on protein aggregates to modify the existing signals and subsequent cell fate [ 176].
A cycle uses those steps to extend the length of existing contigs, and subsequent cycles repeat the process using the output of the prior cycle as input.
Because this study was performed in vivo, we consider that the expression of the catabolic genes may have led to degradation of the existing matrix and subsequent proliferation and synthesis of new matrix in the limited articular cartilage space.
This is the stereotypical consequence of selective impairment of translation initiation, involving a decrease in new initiation events, "run-off" of elongating ribosomes from existing polysomes, and subsequent accumulation of excess free subunits as 80S couples.
In combination, these convergent lines of evidence suggest that co-option of duplicated genes in existing pathways and subsequent neofunctionalization are likely to have contributed to the evolution of the lamellocyte-mediated encapsulation in Drosophila.
This process was repeated with each subsequent transcript, integrating existing and emergent codes.
Study existing and well-established micronations.
Linear inverse modeling (LIM) allows missing flow values to be estimated from existing flow observations and, subsequent reconstruction of ecosystem food webs.
In general, sites found value in targeting the age group of 50 and over, focusing on health rather than routine HDSS questions, linking INDEPTH WHO-SAGE data with existing HDSS variables and subsequent health outcomes.
