Existing structural alteration detection tools are limited by their reliance on read-mapping tools designed for the short read-sequences produced by the original HTS technologies; they cannot take advantage of increasing read length.
Our data indicate that clozapine may be reversing or compensating for a pre-existing alteration in serotonergic neurotransmission in schizophrenic patients.
It is unclear, however, to what extent ACE-inhibitors can also reverse existing cardiovascular alterations.
> > The question as to whether propensity to POAF can be explained by pre-existing alterations of ion-channel function in these patients has been addressed by several investigators.
Given frequent and sometimes co-existing alterations in the RAS and PI3K pathways in low-grade serous OC, combination studies of MEK and PI3K inhibitors may be appropriate in this subgroup.
To identify oncogene candidates within the 9p13 region, we leveraged existing whole genome alteration data from OPLs and oral tumors and global gene expression data from oral tumors.
God's alteration of existing mazal through name change is a concept upheld even to this day.
However, it remains uncertain whether genomic alterations existing in primary tumor tissues are represented in cell lines and whether cell lines carry cell line-specific genomic alterations.
The impasse -- which the board says will save $100 million -- means that the city's teachers union now faces two options: either re-opening the existing contract for alterations, potentially paving the way to a teachers' strike, or beginning negotiations for the next contract, as the union's vice president Jesse Sharkey explained to the Sun-Times.
Of note, most studies examining FLT3-ITD in cell lines, have introduced the FLT3-ITD mutation into an already transformed cell with existing mutations and alterations.
In general, this investigation disclosed that the clinical course pursued following muscular inactivity of the shoulder, regardless of the cause, is directly dependent upon the degree of degenerative alterations existing in the structures comprising the scapulohumeral joint.
