Mr. Fox, the chief executive of BuySide, a start-up that operates in five states, says his company is working harder to get along with existing agents.
Classes of effective therapeutics are needed owing to the emergence of drug resistance as well as the toxicity of existing agents.
Recent developments in measuring cough support some existing agents but investment in modern studies to provide comprehensive proof of efficacy has not happened.
Thus, the development of new formulations of existing agents, designed to overcome current resistance patterns, constitutes a potentially important additional strategy towards appropriate prescribing.
It appears, nonetheless, that introducing new chemotherapy agents into the adjuvant setting is a more promising strategy than attempting to optimize the dose and schedule of existing agents.
Studies of radiolabeled ligands to map subreceptors may provide specification of wanted drug properties to guide the choice among existing agents or to synthesize novel ones.
In conclusion, RA has single-agent activity in relapsed, sensitive SCLC with manageable toxicities but is unlikely to provide any superiority compared to existing agents for this disease.
(Kennedy taught himself screenwriting after adapting his novel Legs for the screen, fired his existing agents and hired the kind of movie agent at William Morris who "got me more money at a 15-minute luncheon to write a treatment than I'd made all year as a teacher").
"You owe it to the consumer, be they purchaser or seller, to provide them with agents trained in the company's image, and we owe it to existing agents and shareholders as well as consumers to be sure that everyone whose license in held by our firm is trained in the same way".
New biocompatible high-atomic number contrast materials with different biodistribution and X-ray attenuation properties than existing agents will expand the diagnostic power of spectral CT imaging without penalties in radiation dose or scan time.
A major challenge for the field will be to develop predictive biomarkers of response, and to identify mechanisms of resistance to existing agents that can be addressed in subsequent clinical trials.
