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'existential significance' is a correct and usable phrase in written English.
You can use it when discussing philosophical topics, such as the meaning of life. For example: "This life event has existential significance for me, as it has helped me to reassess my values and goals."
Exact(10)
The erotic symbolism of food abounds; the existential significance of the yarmulke sputteringly drives the story.
Just as in the presidential race, those involved see it as having an almost existential significance.
Thus, their exploration has existential significance for humanity's self-regard, and indeed perhaps of our place in the natural scheme.
His first book began with a discussion of time, and argued that the mounting evidence that humans had altered the weather was of profound existential significance.
If the Islamic State suicide bombers who attacked the Stade de France on Friday 13 November had succeeded in entering the stadium, as appears to have been their intention, France might now be facing an additional crisis of political, constitutional and existential significance: namely, the assassination of the president of the republic.
Man was a product of external forces, an insignificant piece in a cosmic puzzle, without dignity, freedom, responsibility, or fundamental existential significance.
Similar(50)
We thus continue to identify the ecological, cultural and existential significances of how local environments shape the histories of diverse human communities in the greater Himalayan region.
Surfaces are so incredibly fragile and fleeting, and ultimately empty of the deepest existential meaning or significance.
The significance of sense for Nancy rests in this co-being, where existential meaning is created in each contact.
The omnipresent racket is obviously some kind of symbol, in the existential way: its significance may be that it has none.
The former argues that we should dispense with treating race as an ontological reality, while the latter argues for both the existential and epistemological significance of racial difference.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com