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"existential challenges" is a correct and usable phrase in written English.
It is used to refer to the bigger questions in life, such as the meaning of life, one's place in the world, and the purpose of existence. For example, "Life is full of existential challenges that force us to confront our own mortality."
Exact(40)
Europe faces huge existential challenges.
Thailand faces truly existential challenges.
This is about real, consequential, life-and-death, existential challenges to our nation and others.
The book fails, quite profoundly, to address the existential challenges that these places without placeness will trigger.
At its best, it was not about the techniques of crime fighting so much as it was about its existential challenges.
There is another reason for the current nuclear push – part mischievous, part sincere and all in response to one of humanity's existential challenges – climate change.
Similar(19)
Winning them back is an existential challenge.
That's our real existential challenge.
Rather it is the existential challenge to the messy democracy we've devised.
There are, of course, days when Bass Strait does not pose nearly the same existential challenge.
The advent of the Internet presented an existential challenge to bundles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com