Although the heat map displays in Figure 5c imply the existence of remote SNPs in tight LD across the two genes, the textile plot provides a much clearer view of the remote SNPs by a simple rearrangement of the SNP ordering.
Existence of remote cis-acting elements controlling BDNF transcription has been demonstrated by recent studies describing a regulatory region 850 kb upstream of human and mouse BDNF genes, disruption of which causes obesity, cognitive impairment, and hyperactivity (Gray et al., 2006; Sha et al., 2007).
It is found that dynamic buckling may lead sometimes to an unbounded motion regardless of the existence of another remote stable equilibrium position, while in other cases the latter position may act as point attractor capturing the motion.
To further explore the existence of putative very remote homologs, we lowered the confidence probability threshold of HHsearch to 70%.
On the contrary, the potential existence of arrhythmogenic substrates remote from the PVs was evaluated by the assessment of AF inducibility, either through atrial burst pacing or administration of isoproterenol.
One lived in Perak, in a small town called Parit, not far from Batu Gajah, in turn not far from Ipoh, the state capital; the other had a more peripatetic existence, moving from a series of remote jungle towns — Tumpat, Temangan — before settling in Kuala Krai, in the heart of the Islamic state of Kelantan, on the remote northeastern coast of Malaysia.
Indeed, previous studies have reported the existence of preferred sites among remote homologues and even between structurally similar although not necessarily related proteins [6,7].
To narrow the list of possible candidates for the other Tyr radical site, remote from the heme and located in the distal-side region as indicated by the effect of the Trp51 substitution, we took into consideration the existence of the substrate binding site remote from the heme recently reported by Raven and co-workers.
False affirmative sentences about a remote matter maintain the existence of compounds which are necessarily non-existent; they are called impossible.
To explore for the existence of an auxiliary hydrophobic binding register remote from the active site of PSMA a series of phenylalkylphosphonamidate derivatives of glutamic acid were synthesized and evaluated for their inhibitory potencies against PSMA.
The glory awarded SOF operators in movies and at public spectacles, divorced from any wider sense of shared sacrifice, only makes their existence more remote.
