Sentence examples for existence of a defect from inspiring English sources

In conclusion, this study demonstrates the existence of a defect in autophagy in human and mouse muscular dystrophy, and that a treatment restoring autophagy ameliorates the dystrophic phenotype.

A particularly attractive mechanism that could account for hypokalaemia is the existence of a defect in the renal K+/H+ ATPase pump.

We tested the hypothesis of the existence of a defect in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) in ovarian tumours that could cause reduced intracellular regeneration of the 5-methyltetrahydrofolate and induce increased FBP expression.

The RW method was significantly correlated with the physicians' heterogeneity perception but is influenced by the existence of a focal defect.

Our results infer that the existence of a successive defect structure with multiple traps for the incorporation of the shallow and deep ones is conducive to the thermal stability of SrGa2O4 Tb3+ phosphor, which could provide a potential application in a rigorous environment with a higher thermal energy than the room temperature, such as solar energy utilization, and in vivo-imaging.

Five steps are necessary to develop a tension gastrothorax: (1) existence of a diaphragm defect, (2) increased intraabdominal pressure, (3) prolapse of the stomach into thoracic cavity, (4) a functional change in the gastroesophageal junction (by way of an abnormal angulation) to form a one-way valve, and (5) a reduction in cardiac output as a result of mediastinum shift [2, 3].

Moreover, in support of the existence of a BM defect in human DM, we have shown a reduction in BM CD34+ cells, compared with nondiabetic subjects (9).

Therefore, the present prospective trial substantiates the existence of a BM defect in human DM and suggests that the BM mobilization failure precedes reduction of circulating progenitors.

Decreased basal levels of apoptosis and hyperproliferative mucosa have been observed in patients with adenomas, suggesting the existence of a 'field defect' in the colonic mucosa (Anti et al, 2001).

Proving the existence of an intrinsic defect in neutrophils in CF patients would ultimately require well-controlled data in infants, prior to the advent of chronic disease, a feat that has not been achieved so far.

Da Costa and Beardsley first demonstrated the existence of an immune defect in 1907 [ 44].