Sentence examples for existed a major from inspiring English sources

19 In 2006, Boppudi et al. concluded that there existed a major lack of agreement between tumoral changes at CT imaging and changes in CEA level in patients treated by selective internal radiation therapy (SIRT) for unresectable CLM.

However, still there exists a major problem at this stage of applications of crumb rubber concrete, which is the floating of rubber particles when vibrating and compacting fresh Crumb rubber concrete.

There are many opportunities prevalent in space, but for each opportunity there also exists a major challenge.

But there exists a major difficulty, namely, the local extrema or multiple solution complication arising from the highly nonlinear nature of the log-likelihood function.

On the island of Kyushu, there exists a major tectonic structure, known as the Beppu-Shimabara Graben (Matsumoto, 1979), along the northeastern continuation of the Okinawa Trough.

It is worth mentioning that there exists a major difference between the cases of natural convection and forced convection as analysed by others authors, see for example [39].

Though the regulation of FLC expression via chromatin modification provides a paradigm in flowering gene expression, whether there exists a major flowering regulator such as FLC in rice is still unknown (Fig. 1).

The performance achieved through MIMO technology also entails a considerable increase in signal processing complexity in receiver, and there exists a major challenge in designing low-complexity receivers for multichannel wireless systems.

However, in general, there still exists a major barrier for people who are blind to access the graphical information independently in real-time without the help of sighted people.

Perhaps the most important difference is that in vitro studies focus on a clonal population, while in the in vivo experience different populations exist – a major contributing factor that has hindered the progress of treatment.

There exists a major issue over the clarity of published papers and systematic reviews.