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We think all these risk alleles might contribute jointly to the development of MNG and PTC in the Chinese family members; while considering the risk alleles also presented in the proband's father with normal thyroid, it is possible that different pathogenic mechanisms exist to activate the tumor transformation in the family members with thyroid disease.
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It is not yet clear if membrane recruitment is sufficient to promote Rac activation, or if conserved mechanisms exist to activate GEFs where their activity may be needed.
However, it is quite possible that other pathways and various feedback loops exist to activate Bax and thereby to amplify the apoptotic cascade in hematopoietic and other cell types.
It is assumed that, in the process of sprouting angiogenesis, external signals exist to activate PKC ε.
Third, the capacity of S. aureus exists to activate osteoclasts directly or indirectly via increased RANKL expression on osteoblasts [ 34, 35].
Thus, conditions may exist that allow chromosomal sdiA to activate the acrAB, ftsQAZ, or other genes.
It is well established that GABA can activate GABAA channels in pancreatic islets, but so far it has not been shown that the interstitial GABA concentration that exists within the islets is sufficient to activate the native channels [ 8, 12].
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TGF-beta levels increase during viral infection, and significant TGF-beta levels activated by influenza virus exist to induce cell apoptosis [ 86].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com