Hence, the more base pairs (x i, x j ) there exist in the set of structural alignments, the more gain in the gain function is given for the prediction y ij = 1.
Mulder et al. [ 35] mapped GO terms to the domain if all proteins with the given domain do not exist in the set of proteins without the given GO term.
The negative set meets the two requirements: (i) the noneffective pairs cannot exist in the set of 76 effective pairs, and (ii) the number of noneffective (negative) pairs is equal to that of effective (positive) pairs.
The well-known diversity of lifestyles of disparate apicomplexans as well as the age of the phylum (700-900 million years [ 16]) led us to hypothesize that significant differences exist in the sets of transcription factors present in each species.
Additionally, PSA is not reflective of disease persistence or recurrence and no current stand exists in the setting of residual normal prostate or satellite nondominant cancer foci that have not been treated or identified.
Although it was initially approved for use by the FDA in the adjuvant setting for stage III disease, the most robust data exist in the metastatic setting.
For this purpose, we compiled a set of (position, amino acid) pairs containing all pairs that existed in the set of correctly classified sequences and were different from the (position, amino acid) information of the consensus sequence.
Despite the suggested role of the two markers in chronic diseases, a few studies that investigated both PON1 and SAA levels exist in the clinical setting [ 12, 19].
Although such pipelines already exist in the research setting [ 9], manual checks and orthogonal validation of variants are required because of the ongoing development of the analytical approaches.
